COMPARAÇÃO DA CAPACIDADE FUNCIONAL E DA QUALIDADE DE VIDA DE LONGEVOS COM ACESSO AOS SERVIÇOS DE SAÚDE PÚBLICOS OU PRIVADOS

Introdução: o Brasil está entre os países com ritmo mais acentuado de envelhecimento populacional. Nesse contingente, um subgrupo também está em crescimento, os idosos de 80 anos ou mais. Parte da população opta por utilizar serviços de saúde privados em busca de melhor atendimento. Objetivo: comparar a capacidade funcional (CF), a qualidade de vida (QV) e as características sociodemográficas de idosos longevos, usuários de serviços de saúde públicos ou privados. Método: participaram do estudo 78 idosos com média de idade 82,7±2,9 anos, de ambos os sexos, divididos em dois grupos: Grupo 1 – Grupo privado e Grupo 2 – Grupo público. Materiais: Miniexame do Estado Mental (MEEM) para rastreio cognitivo, Escala de Depressão Geriátrica (EDG-15) para avaliação do estado psicológico, Short Physical Performance Battery (SPPB), dinamômetro para avaliar a força de preensão manual para desempenho físico, e questionários World Health Organization Quality of Life Questionnaire-Older Adults Module (WHOQOL-Old) e Word Health Organization Quality of Life Questionnaire-Bref (WHOQOL-Bref) para QV. Resultados: o grupo privado apresentou melhor função cognitiva e maior número de consultas realizadas no último ano; não houve diferença entre os grupos para a CF e a QV. Conclusão: a capacidade funcional e a qualidade de vida de idosos longevos não estão relacionadas ao tipo de serviço de saúde aos quais eles têm acesso. Os resultados mostraram que os grupos com acesso a serviços privados apresentaram melhor desempenho cognitivo e maior número de consultas médicas no último ano

Evaluation of the degradation potential of different advanced oxidation processes for a textile dye mixture: a kinetic study with mathematical modeling and toxicological tests

Studies and research have been developed around the world on environmental pollution. Among the most diverse types of pollutants, textile dyes have attracted attention in the Brazilian Northeast. These compounds, besides being persistent, resist to the conventional treatments applied in the wastewater treatment plants. Thus, the present study evaluated the degradation of the mixture of direct red 23, direct red 227 and direct orange 26 dyes by advanced oxidation processes (AOPs). It was observed that the homogeneous AOPs were more efficient, being able to degrade 100% of the chromophoric groups after the optimization of the variables [H2O2], [Fe] and pH. The reaction kinetics for the photo-Fenton process followed a pseudo-first order non-linear model, with rapid decay of the concentrations in the first 60 min. Aiming to have a methodology capable of predicting the degradation efficiency for the studied processes, it was verified that the artificial neural networks MLP 4-9-3 and MLP 5-6-3 well represent the data from the homogeneous and heterogeneous processes, respectively. A toxicity study was carried out using seeds, bacteria and microcrustaceans and it was found that the intermediate compounds formed during the treatment process act differently for each of them

Perspectives on gender bias in recruitment

No abstract available.publishe

Plasmatic miR-210, miR-221 and miR-1233 profile:Potential liquid biopsies candidates for renal cell carcinoma

Renal cell carcinoma (RCC) represents a challenge for clinicians since the nonexistence of screening and monitoring tests contributes to the fact that one-third of patients are diagnosed with metastatic disease and 20-40% of the remaining patients will also develop metastasis. Modern medicine is now trying to establish circulating biomolecules as the gold standard of biomarkers. Among the molecules that can be released from tumor cells we can find microRNAs. The aim of this study was to evaluate the applicability of cancer-related miR-210, miR-218, miR-221 and miR-1233 as prognostic biomarkers for RCC. Patients with higher levels of miR-210, miR-221 and miR-1233 presented a higher risk of specific death by RCC and a lower cancer-specific survival. The addition of miR-210, miR-221 and miR-1233 plasma levels information improved the capacity to predict death by cancer in 8, 4% when compared to the current variables used by clinicians. We also verified that hypoxia stimulates the release of miR-210 and miR-1233 from HKC-8, RCC-FG2 and 786-O cell lines. These results support the addition of circulating microRNAs as prognostic biomarkers for RCC

Quality of life and socio-demographic factors associated with nutritional risk in Brazilian community-dwelling individuals aged 80 and over: cluster analysis and ensemble methods

IntroductionThe aim of the present study was to use cluster analysis and ensemble methods to evaluate the association between quality of life, socio-demographic factors to predict nutritional risk in community-dwelling Brazilians aged 80 and over.MethodsThis cross-sectional study included 104 individuals, both sexes, from different community locations. Firstly, the participants answered the sociodemographic questionnaire, and were sampled for anthropometric data. Subsequently, the Mini-Mental State Examination (MMSE) was applied, and Mini Nutritional Assessment Questionnaire (MAN) was used to evaluate their nutritional status. Finally, quality of life (QoL) was assessed by a brief version of World Health Organizations’ Quality of Life (WHOQOL-BREF) questionnaire and its older adults’ version (WHOQOL-OLD).ResultsThe K-means algorithm was used to identify clusters of individuals regarding quality-of-life characteristics. In addition, Random Forest (RF) and eXtreme Gradient Boosting (XGBoost) algorithms were used to predict nutritional risk. Four major clusters were derived. Although there was a higher proportion of individuals aged 80 and over with nutritional risk in cluster 2 and a lower proportion in cluster 3, there was no statistically significant association. Cluster 1 showed the highest scores for psychological, social, and environmental domains, while cluster 4 exhibited the worst scores for the social and environmental domains of WHOQOL-BREF and for autonomy, past, present, and future activities, and intimacy of WHOQOL-OLD.ConclusionHandgrip, household income, and MMSE were the most important predictors of nutritional. On the other hand, sex, self-reported health, and number of teeth showed the lowest levels of influence in the construction of models to evaluate nutritional risk. Taken together, there was no association between clusters based on quality-of-life domains and nutritional risk, however, predictive models can be used as a complementary tool to evaluate nutritional risk in individuals aged 80 and over

PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS DO ENVELHECIMENTO DA UNIVERSIDADE SÃO JUDAS TADEU: TRAJETÓRIA E PANORAMA ATUAL

O Programa de Pós-Graduação em Ciências do Envelhecimento (PGCE), nível mestrado, foi aprovado pela CAPES em 2009 e iniciou suas atividades em 2010. É o único programa de pós-graduação de uma universidade privada com foco em Gerontologia na cidade de São Paulo. Atualmente, o PGCE está organizado em uma área de concentração denominada Ciências do Envelhecimento e em três linhas de pesquisa: (1) Aspectos educacionais, psicológicos e socioculturais do envelhecimento; (2) Doenças associadas ao envelhecimento; e (3) Saúde e funcionalidade no envelhecimento. Esta revisão narrativa apresenta a descrição dos atuais projetos de pesquisa do PGCE, conforme apresentado no relatório para avaliação de 2017 a 2020, recentemente submetido à CAPES. No período acima referido, a produção científica do PGCE correspondeu a 331 produções: 54 artigos em periódicos, 15 capítulos de livros, 36 trabalhos em anais de congressos, 91 apresentações de trabalhos em congressos e 135 produções técnicas. Ao longo de sua trajetória, algumas mudanças destacaram as características interdisciplinares do PGCE, o que pode ser evidenciado pelo aumento: na qualidade dos artigos publicados, no número de alunos matriculados, de dissertações apresentadas e de projetos de pesquisa e extensão desenvolvidos no período de 2017 a 2020, em comparação com o período de 2013 a 2016. O PGCE é um programa dinâmico que se adapta às necessidades emergentes da sociedade, integra pesquisa e extensão e, ao mesmo tempo, apresenta uma produção robusta para a comunidade científica

Epidemiology of Psoriasis in Portugal: A Population-Based Study

Introduction: Psoriasis is a common, chronic, and inflammatory skin disorder with a high personal, social and economic burden and important implications for healthcare systems. The aim of this study was to provide an epidemiological characterization of individuals with psoriasis in Portugal. Material and Methods: A large observational, cross-sectional, nationwide, population-based survey study developed by the Portuguese Psoriasis Group of the Portuguese Society of Dermatology and Venereology (GPP-SPDV). A structured questionnaire was designed and applied by experienced interviewers to a random, representative sample of Portuguese individuals with psoriasis and/or psoriatic arthritis. Patients were considered to have psoriasis if they replied positively to one of the following questions: “Does any physician have ever diagnosed you with psoriasis?” or “Do you have a skin disorder characterized by scaling, reddish skin lesions located in the elbows/knees/scalp?”. Results: A total of 6381 individuals were interviewed, of which 283 met the criteria for psoriasis, corresponding to a prevalence rate of 4.4% (95% CI 3.95 – 4.98). Out of the participants that met psoriasis criteria, 24% had suggestive signs/symptoms but did not have a clinical diagnosis established and were not being monitored by a physician. Although more than 70% of participants had active disease (scaling, erythema, or pruritus) and one third had joint symptoms, only 12% were on systemic treatment. Fifty percent of participants with psoriasis (n = 139) had relevant comorbidities (most frequently depression/anxiety and cardiometabolic diseases). Sixteen percent of participants with psoriasis (n = 46) reported that psoriasis interfered with their daily activities (median impact of 5 in a 0 – 10 scale) and 12% mentioned the disease had an impact in their sexual life (median impact of 5 in a 0 – 10 scale). Conclusion: The results of this study suggest that the prevalence rate of psoriasis is likely to be high in Portugal, and several gaps exist at different levels of healthcare delivery to these patients, from diagnosis to treatment. This study provides important data for the future planning of interventions targeting the improvement of psoriasis care in Portugal

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery